New methods, new information, and new insight: cases of single-molecule biophysical experiments

Seok-Cheol Hong (Korea Univ.)

New methods often open up a new horizon in traditional sciences. The breakthrough of single-molecule biophysics is an epitome of such revolutions. Single molecule biophysical approaches allow us to make direct observation of and to gain qualitative results for biological phenomena, and thus to make unambiguous conclusions for them. The interpretation made as such can be further consolidated by simultaneous, thus correlated acquisition of the data offered by various independent single-molecule methods. As examples of broadening the scope of research via new single-molecule approaches, I will describe two of our recent experiments: dissection of the mechanism of cisplatin, a well-known anti-cancer drug, and unveiling the mechanistic details of the B-Z DNA transition.